Savory Southern Meatloaf Recipe Your Family Will Love

Last Updated on February 12, 2026 by Antoni Recipes Team

There s something wonderful about the smell of a freshly baked meatloaf wafting through your home, reminiscent of cozy family gatherings and hearty Sunday dinners. My journey into the world of cooking took a delightful turn when I experimented with this Southern Meatloaf recipe, achieving a perfect balance of savory flavors and juicy textures. In just 10 minutes of prep, this comfort food classic comes alive, making it an easy solution for those weeknight dinners when you want something that pleases both kids and adults alike.

What truly sets this recipe apart is its versatility whether you stick with traditional ground beef or explore leaner options like turkey, each bite is sure to resonate with anyone craving the nostalgia of home-cooked meals. Paired with creamy mashed potatoes or seasonal veggies, this dish transforms any meal into a feast. Join me as we dive into crafting this mouthwatering Southern Meatloaf that s not just a quick-fix but a recipe to cherish for years to come.

Why is this Southern Meatloaf Recipe a must-try?

Comforting and Familiar: The classic flavors are reminiscent of home-cooked meals, perfect for cozy family gatherings.
Quick Prep Time: Whip it up in just 10 minutes, making it an ideal weeknight solution.
Flavorful Glaze: The sweet and tangy glaze adds a delightful touch that kids and adults love.
Versatile Ingredients: Easily swap out the meat and breadcrumbs to fit your dietary preferences.
Satisfaction Guaranteed: Each juicy slice is guaranteed to be a crowd-pleaser, turning any dinner into a memorable feast.

Southern Meatloaf Ingredients

For the Meatloaf
Plain Dried Breadcrumbs Provides structure to the meatloaf; can be substituted with crushed Saltines or quick-rolled oats for a gluten-free version.
Kosher Salt Enhances flavor and balances the meat s richness; don t skip this essential ingredient.
Black Pepper Adds mild heat and depth; freshly ground is preferred for the best flavor.
Garlic Powder Contributes savory notes; consider using fresh minced garlic for an aromatic twist.
Onion Powder Provides sweetness and aroma; you can substitute with finely minced fresh onions for extra freshness.
Milk Maintains moisture, ensuring a tender meatloaf; any type of milk, including plant-based, works well.
Large Egg Acts as a binder for the meatloaf mixture; extra-large eggs can be used if needed.
Worcestershire Sauce Adds savory umami flavor and depth; soy sauce can be an alternative for a different taste.
80/20 Ground Beef The primary protein source, ensuring juiciness; a blend of ground turkey or pork can be used for a leaner version.
Small Yellow Onion Provides an aromatic foundation; you can use shallots for a milder taste.

For the Glaze
Good-Quality Ketchup Creates the signature glaze; essential for flavor, or try using BBQ sauce for a twist.
Brown Sugar Adds sweetness to the glaze; honey or maple syrup can substitute for a different flavor profile.

How to Make Southern Meatloaf

1. Preheat Oven: Begin by setting your oven to 350 °F (175 °C). Line a rimmed sheet pan with foil, preferably nonstick, to prevent sticking and make cleanup a breeze.
2. Mix Meatloaf Base: In a large mixing bowl, combine breadcrumbs, salt, pepper, garlic powder, and onion powder. Pour in the milk, add the egg, and drizzle in the Worcestershire sauce to bring all the flavors together.
3. Combine with Meat: Add the 80/20 ground beef and the minced yellow onion to your mixture. Gently combine using your hands, taking care not to overmix it for a tender meatloaf.
4. Shape Loaf: Transfer your meat mixture to the prepared pan. Shape it into a narrow loaf, making sure to flatten the top slightly for even cooking.
5. Prepare Glaze: In a small bowl, whisk together the ketchup, brown sugar, Worcestershire sauce, salt, garlic powder, onion powder, and black pepper until smooth and well combined.
6. Bake First Round: Pour half of the glaze over the meatloaf. Bake it in the preheated oven for about 35 minutes until it s just starting to set.
7. Add Remaining Glaze: After the initial baking, remove the meatloaf from the oven and add the remaining glaze on top. Return to the oven and bake for an additional 30-35 minutes until fully cooked and caramelized.
8. Rest and Serve: Once done, let the meatloaf rest for about 15 minutes before slicing. This step allows the juices to redistribute, making for a perfectly sliced meatloaf.

Optional: Serve with creamy mashed potatoes or seasonal vegetables for a delightful meal.
Exact quantities are listed in the recipe card below.

Southern Meatloaf Recipe Variations

Feel free to explore these delightful twists to make this recipe your own, adding new flavors and textures!

• Lean Turkey: Swap ground beef for ground turkey to create a lighter version while still enjoying that classic meatloaf taste.
• Cornbread Crumble: Substitute dried breadcrumbs with crushed cornbread for a delightful Southern twist, adding a hint of sweetness.
• Gluten-Free: Use gluten-free breadcrumbs or rolled oats to ensure this comforting dish is accessible for those with gluten sensitivities.
• Spiced Kick: Add a teaspoon of red pepper flakes to the meat mixture for a subtle heat that warms the soul without overpowering the overall flavor.
• Vegetable Boost: Incorporate grated zucchini or finely chopped spinach into the meat mixture to sneak in some extra nutrients and moisture.
• Savory Herbs: Enhance flavor by mixing in fresh chopped parsley or thyme to the meat mix for a fragrant herbaceous note.
• Exotic Glaze: Experiment with different glazes using honey mustard or a tangy chipotle sauce to switch up that traditional ketchup finish.
• Nutty Crunch: Stir in some chopped pecans or walnuts for added texture and a delightful nutty flavor that complements the meat beautifully.

Make Ahead Options

These Southern Meatloaf meals are perfect for busy home cooks looking to save time during hectic weeknights! You can prepare the meatloaf mixture (without baking) up to 24 hours in advance, simply cover it tightly and refrigerate. Additionally, you can pre-mix the glaze and store it in an airtight container for quick access when you re ready to bake. When you re set to enjoy this comforting dish, just shape the loaf and bake, adding the glaze halfway through the cooking process. This way, you ensure it s just as delicious and juicy, while keeping your weeknight meals effortless and stress-free!

What to Serve with Juicy Southern Meatloaf with Sweet and Tangy Glaze?

Nothing elevates a comforting meatloaf like the perfect side dishes, enveloping your dining experience in warmth and flavor.

• Creamy Mashed Potatoes: The velvety richness of mashed potatoes complements the savory meatloaf, creating a classic comfort food pairing that feels like a warm hug.
• Green Beans Almondine: Crisp-tender green beans sprinkled with toasted almonds add a fresh crunch to your plate, balancing the hearty meatloaf with vibrant flavors.
• Southern Cornbread: This slightly sweet, crumbly bread absorbs the luscious glaze perfectly, making each bite burst with flavor and nostalgia.
• Roasted Seasonal Vegetables: A medley of roasted carrots, zucchini, and bell peppers brings both color and sweetness, enhancing the meatloaf s savory notes while providing a nutritious touch.
• Buttery Biscuits: Soft, flaky biscuits are perfect for mopping up any leftover glaze, turning each meal into an opportunity for indulgence.
• Sweet Potato Fries: The natural sweetness of crispy sweet potato fries contrasts delightfully with the tangy glaze, adding a fun twist to your comfort food ensemble.
• Coleslaw: A light and creamy coleslaw provides a refreshing crunch, cutting through the richness of the meat, making it a great palate cleanser.
• Homemade Applesauce: An unexpected but delightful pairing, tart applesauce offers a refreshing burst of sweetness that complements the savory flavors.
• Iced Tea or Lemonade: Quench your thirst with a glass of classic iced tea or zesty homemade lemonade. Both drinks offer a perfect cooling counterpoint to your warm meal.

Expert Tips for Southern Meatloaf

• Avoid Overmixing: Handle the meat mixture gently to prevent a dense meatloaf. Overmixing can lead to a chewy texture, so keep it light!
• Resting is Key: Let the Southern meatloaf rest for 15 minutes after baking. This helps the juices redistribute, making slices cleaner and more flavorful.
• Quality Glaze: Always opt for high-quality ketchup in your glaze. It elevates the flavor profile significantly, making your meatloaf unforgettable.
• Experiment with Meats: Don t be afraid to switch up the ground meat. Ground turkey or a combination of pork and beef can give you a delicious and healthier twist!
• Pan Options: If you don t have a rimmed sheet pan, use a loaf pan. Just remember to adjust the baking time slightly, as moisture can vary!

How to Store and Freeze Southern Meatloaf

Fridge: Store leftover Southern meatloaf in an airtight container for up to 3-4 days. This keeps it fresh and ready for quick dinners.

Freezer: For longer storage, wrap individual slices in plastic wrap and then in aluminum foil, or use a freezer-safe container for up to 2-3 months.

Reheating: To reheat, thaw in the fridge overnight, and then bake in a preheated oven at 350 °F (175 °C) for 15-20 minutes until heated through.

Make-Ahead: Prepare the meatloaf a day in advance; just keep it covered in the fridge until you re ready to bake, making weeknight meals even easier!

Southern Meatloaf Recipe FAQs

What type of breadcrumbs should I use for the Southern meatloaf?
Using plain dried breadcrumbs is traditional, as they provide great structure. However, if you re looking for a gluten-free option, crushed Saltines or quick-rolled oats work wonderfully as substitutes.

How long can I store leftover meatloaf in the fridge?
Absolutely! Store your leftover Southern meatloaf in an airtight container for up to 3-4 days. Just make sure it s properly sealed to keep the moisture in!

Can I freeze Southern meatloaf, and how should I do it?
Yes, you can freeze it! Wrap individual slices in plastic wrap, then in aluminum foil, or place them in a freezer-safe container. This keeps them fresh for up to 2-3 months. To reheat, simply thaw in the fridge overnight, then bake at 350 °F (175 °C) for about 15-20 minutes.

What if my meatloaf is too dry after baking?
If you find your meatloaf is dry, it may be due to overbaking or insufficient moisture in the mix. For the next time, make sure to measure the milk correctly and keep a close eye on cooking times. You could also add a bit more Worcestershire sauce or an extra egg to help with moisture!

Are there any dietary considerations for pets, allergies, or specific diets?
This Southern Meatloaf recipe contains common allergens like eggs and dairy, so be cautious if you have allergies to those ingredients. If you re cooking for pets, it s best not to share this dish directly due to the onions and seasonings. Consider making a simple, unseasoned version for them instead!